Often, the very first symptom of a bone cancer (osteosarcoma, Ewing's sarcoma and many others) is a continuous, deep leg pain, most commonly at night.

  Later, person may develop fevers and become cachectic.

Did You Know That...

Colds are caused by over 100 different viruses.  For this reason, it is much more difficult to find a vaccine for a cold, than it is for a flu.